MOTS-c 20mg

£85.00

MOTS-c is a 16-amino acid mitochondrial peptide with a key role in regulating cellular energy metabolism .
Synthesized within the mitochondria, it affects glucose metabolism, insulin sensitivity, and the response to oxidative stress , promoting metabolic rebalance and cellular vitality.
Studies show that MOTS-c improves physical performance, reduces obesity and insulin resistance , supports cardiovascular health , and counteracts the effects of metabolic aging .
For these reasons, it is considered a peptide of great interest in research on longevity, metabolism, and muscle regeneration.

MOTS-c 20mg is a 16-amino acid mitochondrial peptide belonging to the mitochondrial-derived peptides (MDPs) , a family of small bioactive molecules produced by mitochondria that participate in intracellular communication and energy homeostasis. Experimentally, it is being studied for its ability to modulate the use of energy substrates, support insulin sensitivity , and promote adaptive responses to metabolic stress . Interest in MOTS-c also stems from its potential impact on processes related to obesity , diabetes , aging , and tissue integrity, serving as a “messenger” between the mitochondrion and the nucleus.

Liver, mitochondria and insulin resistance

MOTS-c 20mg, Mitochondrial dysfunction in the liver can promote ectopic lipid accumulation , reduced fat oxidation, and the onset of insulin resistance . In unfavorable dietary scenarios (e.g., high-fat diets or excessive fructose), mitochondria lose efficiency, with cascading effects on obesity , hepatic steatosis , and altered glucose metabolism. MOTS-c, by modulating cellular energy programs and the redox system, is being studied as a lever to restore a more favorable metabolic balance and counteract the key features of hepatic metabolic dysfunction.

In summary

MOTS-c is a bioenergetic modulator that acts on multiple fronts: muscle (glucose uptake and mitochondrial efficiency), adipose tissue (lipid oxidation, thermogenesis, inflammation), liver (redox balance and lipid management), bone (collagen and osteogenic differentiation), and endothelium (vascular reactivity). Through pathways such as AMPK and TGF-β/SMAD , it helps restore energy homeostasis and support cellular resilience . This profile makes it a molecule of primary interest in the biology of aging and metabolic disorders, always and exclusively within the scope of laboratory research .

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