MOTS-c
MOTS-c 10mg Mitochondrial peptide for research on metabolism, longevity, cellular function, and energy regulation.
What is MOTS-c
MOTS-c is a 16-amino acid mitochondrial peptide belonging to the mitochondrial-derived peptides (MDPs) , a family of small bioactive molecules produced by mitochondria that participate in intracellular communication and energy homeostasis. Experimentally, it is being studied for its ability to modulate the use of energy substrates, support insulin sensitivity , and promote adaptive responses to metabolic stress . Interest in MOTS-c also stems from its potential impact on processes related to obesity , diabetes , aging , and tissue integrity, serving as a “messenger” between the mitochondrion and the nucleus.
MOTS-c and muscle metabolism
In skeletal muscle , MOTS-c is being investigated for its ability to promote glucose uptake and the efficiency of ATP production. By activating the AMPK pathway , it increases the translocation of glucose transporters and promotes the use of energy substrates, even when the insulin response is reduced. In preclinical models, this is associated with improved metabolic performance , support of lean mass , and a reduction in fatigue, with a profile that partially overlaps with the effects of physical exercise ( exercise-mimetic action ).





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